Former PhD Student Dr. Donald Thevalingam was very intrigued with the enhancement of brain hyaluronan which has been identified in the African naked mole-rat. He set out to explore how this enhancement may influence the extracellular space of the brain in this species. This work is the result. It was accomplished through a wonderful collaboration with the Hrabetova Lab at SUNY Downstate. The conclusions of this work may cause ust to re-think how the brain accomplishes hypoxia tolerance in these extremophile rodents.